The city of Isernia has ancient origins, man lived there since the Paleolithic period, it was an important area of the Samnites. In 263 B.C., it was subdued to Rome, which made it a Latin colony: "Aesernia". Over time, it has alternated periods of splendor with periods of decline. It has been destroyed several times by wars and earthquakes. In 1970, Isernia was elevated to a provincial capital. Today, a heavy economic and employment crisis is leading it to a new period of decline.